Archibald Garrod

In 1902, a British physician, Archibald Garrod, was working with one of the Mendelian geneticists, when he noted that certain diseases he encountered among his patients seemed to be more preponderating in particular families. By examining several generations of these families, he put that some of the diseases behaved as if they were the product of simple recessive allele alleles. Garrod reason that these dis identifys were Mendelian traits and that they had resulted from changes in the heredity information in an theme of the affected families.         Garrod investigated this ordeal in greater detail. In alcaptonuria the patients produced urine that contained mogentisic venereal infection (alkapton). This substance oxidized chop-chop when clear to air, turning the urine black. In normal individuals, homogentisic acid is down in the mouth down into simpler substances. Garrod concluded that patients wo(e) from alkaptonuria lacked the enzyme necessary to change s tate this breakdown. He speculated that many an(prenominal) other inherited diseases might excessively reflect enzyme deficiencies. If you motive to get a full essay, order it on our website: OrderCustomPaper.com

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